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Kotanová J., E. Köhlerová, J. ·karda: Contrasting Ability of Steroidal (ICI 182 780) and Non-steroidal (EM-800) Antiestrogen to Inhibit Reproductive Organ Growth in Male and Female Mice. Acta Vet. Brno 2005, 74: 533-541. The changes in mammary, uterine and seminal vesicle growth were intended to identify the in vivo activity of estrogen antagonists. Using the combinations of hormone agonist and antagonist, we tested and compared four model systems, the young intact and adult gonadectomized male and female mice. Steroidal antiestrogen ICI 182 780 (ICI) always behaved as an antiestrogen: ICI alone or in combination with estradiol (E) or progesterone (Prog) decreased mammary and uterine growth in prepubertal and adult ovariectomized (OV-X) females and decreased mammary growth in prepubertal adult castrated males treated with E. In prepubertal males ICI alone or in combination with Prog or E also increased seminal vesicle weights. Nonsteroidal antiestrogen EM- 800 (EM) alone, on the other hand, had no effect on mammary and uterine growth in prepubertal females, and in adult OV-X females uterine growth was even stimulated by EM alone, and a combination of EM plus Prog stimulated not only uterine growth but also mammary growth ( the estrogenic effects). EM synergized with E in decreasing seminal vesicle weights in E treated prepubertal males. However, EM decreased E stimulated mammary growth in prepubertal and adult gonadectomized females and males and E stimulated uterine growth in prepubertal and adult OV-X females. EM increased Prog stimulated seminal vesicle weights in prepubertal males (the antiestrogenic effects). Antiestrogen, growth, mammary gland, uterus, seminal vesicles, mice

Contrasting Ability of Steroidal (ICI 182 780) and Non-steroidal (EM-800) Antiestrogens to Inhibit Reproductive Organ Growth in Male and Female Mice