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Young intact (18 days of age) and adult gonadectomized C3H/Di mice were used 10 Study the biological effects of norethindrone acetate (NA) and utilization of -NA stimulated/inhibited mammary, uterine, seminal vesicles and spleen growth as a test system for identification of androgenic activities. Females were treated for 10 days, males for 15 days. Mammary glands of NA-treated animals showed a progressive lengthening and branching of ducts, and appearance of alveolar buds and interductal lobuloalveolar structures from the dose 3.125 in females and 12.5 mug.d(-1) in mates. NA from the dose of 12.5 mug.d(-1) increased uterine weight,,, and decreased seminal vesicle weights in young intact animals. NA had no androgenic effect oil seminal vesicle weights in castrated males. NA mimicked the effect of a combination of estradiol Plus progesterone in all organs studied. Testosterone alone had no effect oil mammary growth in both sexes,, however uterine and seminal vesicle weight, were increased. Uterine weight was increased by testosterone at considerably higher (3000fold in young intact, 500fold in ovariectomized animals) doses than by estradiol. Mammary growth stimulated by moderate doses of NA (125 and 25 mug.d(-1) in females; 25 and 50 mug.d(-1) in males) was inhibited by testosterone. In uterus, however, testosterone acted cooperatively with moderate doses of NA to produce a higher uterine growth than that observed in animals injected with testosterone or NA alone. In Young intact males, NA caused reduction in seminal vesicle weights was abolished by simultaneous application of testosterone.

Norethindrone Acetate and Testosterone Interactions in Mammary Gland, Uterus and Seminal Vesicles of Mice