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Vajner L., J. Uhlík, V. Konrádová, J. Zocová: The Effect of Intravenously Administered Acetylcholine on the Glycoconjugate Composition in Goblet Cells of the Tracheal Epithelium in Rabbits. Acta Vet. Brno 2000, 69: 17-23. To evaluate the influence of cholinergic stimulation on the composition of glycoconjugates in goblet cells, we studied the tracheal epithelium of rabbits 5 minutes and 20 minutes after i.v. administration of acetylcholine in doses 0.1 mg and 0.5 mg, respectively. Using both conventional and lectin histochemistry, we compared the percentage of tracheal goblet cells containing neutral glycoconjugates to those containing total acidic glycoconjugates, sulphated acidic glycoconjugates, and sialylated acidic glycoconjugates. A conspicuous increase in percentage of neutral glycoconjugates-containing goblet cells and a decrease of sialylated glycoconjugates- containing goblet cells occurred as early as 5 minutes after the administration of the lower dose and were recorded 20 minutes post exposure, too. Five minutes post exposure, the higher dose evoked a decrease in percentage of both neutral- and sialylated glycoconjugates-containing goblet cells. Twenty minutes after the administration of the higher dose, percentage of all studied elements reached values similar to those found in the lower dose group. The cholinergic stimulation did not cause total disappearance of both neutral- and sialylated glycoconjugates-containing goblet cells. Only the reaction of goblet cells 5 minutes after the administration of the higher acetylcholine dose differed quantitatively from the reactions in remaining experimental groups. Airways' epithelium, cholinergic stimulation, glycoconjugates, lectin histochemistry In our previous studies, we demonstrated that the goblet cells (GC) in the rabbit tracheal epithelium were overstimulated and damaged due to the intravenous (i.v.) administration of acetylcholine. An apocrine type of secretion and also chain exocytosis were found after the administration of both doses of acetylcholine. Twenty minutes after the administration of 0.5 mg of acetylcholine, the degeneration of GC evoked massive differentiation of new secretory elements (Konrádová et al. 1996ab). Similar reaction of GC was also described by S pecian and N eutra (1980) in the tissue culture of intestinal GC, and by Newman et al. (1996) in the tracheal epithelium of guinea pigs. Tokuyama et al. (1990) and Fung et al. (1992) confirmed the stimulating effect of

The Effect of Intravenously Administered acetylcholine on the Glycoconjugate Composition on Goblet Cells of the Tracheal Epithelium in Rabbits