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Malo taL.. T. R use k. O. S Y n e k: E66e~ 06 OIULt AdminM.tNit..J..Ort 06 Cadmium to P,igle..t6 on lu Cumulation ,in the T ..tA.t.uu o.nd on Co.t.aJ..quc AcUv-LUu 06 MpaILta.te Aminotll.an.t. 6 eJta.6 e, Alan..ine Aminotll.an.t. 6 eJta.6 e and Lac..ta.te VehydAogena6e ~n ~he Blood S~um. ·Acta vet.Brno.56,1987: 79-85. Cadmium was administered to experimental weaned piglets in feed at two different concentrations (50 and 200 mg Cd .• kg-I) to study its effects on catalytic activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT). and lactate dehydrogenase (LDH) and on cadmium ion levels in the blood serum and tissues. The cadmium exerted an activating effect on LHDsnd inhibitory effect on AST catalytic activity at both concentrations. The catalytic activity of ALT. however. was affected by each of the two concentrations in a different way: in animals treated with cadmium at the lower rate it decreased beginning day 7 and fell to the nadir on day 14. whereas in animals treated at the higher rate it rose from day 7. peaking on ~ay 10 of the experiment. Cadmium ion concentration of the blood serum was highest on days 2 and 10. this effect being particularly marked in piglets receiving cadmium ions at the lower rate. The bulk of cadmiuru was cumulated in the kidney and liver. M paJLttLte aminot11.an.6 6 eJta.6 e, alan..ine aminotll.an.t. 6 eJta.6 e, uv~, fUdney, blUWt, la&a.te dehqdAogena6e, cadmium, p.(.glet.

acta veterinaria brno

Effects of Oral Administration of Cadmium to Piglets on Its Cumulation in the Tissues and on Catalytic Activities of Aspartate Aminotransferase, Alanine Aminotransferase and Lactate Dehydrogenase in the Blood Serum