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Flunarizine, a Ca-antagonist, at a concentration of 1μM reversibly depressed Ca-dependent spikes without affecting the resting membrane properties of guinea-pig hippocampal neurons. Flunarizine (1μM) did not affect the EPSPs evoked by focal stimuli, but slightly reduced the duration of evoked IPSPs. When the neurons were superfused with high K+ (60-75 mM) solutions, the membrane potential was irreversibly reduced to approximately 0 mV. The cell deterioration could be prevented by the addition of Co2+ (2mM), a specific Ca2+ channel blocker, to the superfusing solution. Addition of flunarizine (1 μM) also prevented the high K+ induced deterioration. These results indicate that the blockade of voltage dependent Ca2+- influxes by flunarizine prevents the cell deterioration induced by K+-rich media.

Protection by flunarizine from deterioration of hippocampal neurons following exposure to high potassium media.