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A chemical carcinogen, 7, 12 dimethylbenz (a) anthracene, was applied directly to the testis of Wistar rats. After application for ten months, a primary testicular tumor was found in three of nine rats. Histologic examination of the neoplasms indicated that they were primarily squamous cell carcinomas. This is the first report demonstrating induced epidermoid carcinoma in rat testis, although the exact histogenesis remains unknown.

Experimental testicular cancer containing primarily squamous cell carcinoma. A comparative investigation of a rat ovarian cancer.