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In the isolated sartorius muscles, some characteristics of active Na efflux were investigated by washout experiments of radioactive Na, Ca or P with special reference to ouabain action, Ca kinetics and ATP utilization .1) Ouabain affected an accelerated Na-K exchange in the state of the membrane depolarized with Ca++ removal, high K+ or azide. These depolarized states were different in membrane macromolecular conformation from each other when considered from the effect of ouabain on 22Na efflux in every case, and the change in the efflux was not directly interpreted in terms of withdrawal of membrane Ca++2) External Ca ions antagonized the action of ouabain, the relationship between them being probably indirect. The effective concentration of ouabain in suppressing 22Na efflux was higher in Na-loaded muscles than in normal muscles, and it was assumed that an addition of external K+ and ouabain could result in the change in Na+ content by influencing separately on Na pump activity. 22Na net efflux under Na free condition was affected by ouabain and also by externally applied ATP.3) ATP disturbed the effect of ouabain on 22Na efflux but not on its effect on 45Ca dissociation. ATP may behave as an energy source at lower concentrations and may form certain complex to prevent further release of membrane Ca++ at higher concentrations. Labile state of membrane Ca++ caused by ouabain was facilitated by trypsinization but not by lipolysis. Ouabain mobilized transiently membrane Ca++. Ouabain may cause the effect on active Na extrusion by influencing on protein portion of the membrane and this change may simultaneously make membrane Ca++ labile. Moreover, ouabain rendered the phosphorous component of the membrane unstable but this fact did not characterize the effect of this drug on 22Na efflux.

SOME EXPERIMENTS ON OUABAIN-SENSITIVENESS OF 22Na EFFLUX AND AVAILABILITY OF EXOGENOUS ADENOSINE TRIPHOSPHATE IN THE MUSCLE FIBRE MEMBRANE