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Acyclovir is an analog of guanosine nucleoside drug which inhibits viral replication by interrupting DNA chain with high specificity for the herpes virus. It is necessary that consumers of antiretroviral drugs obtain reliable products from pharmaceutical market, and for this, the analytical tests contribute to prove its quality during its shelf life. This work aims to carry out a comparative study in vitro and evaluate the quality of acyclovir 200 mg tablets available in the virtual market. The methods used to perform the physical-chemical quality control testing aspect, assay, dissolution, disintegration, hardness, friability, weight, humidity and uniformity followed the recommendations of the literature. The results indicated that the medicinal products have met with their quality parameters, but presented results of friability, uniformity and moisture content near the maximum limits recommended by the Brazilian Pharmacopoeia, 5th Ed. Therefore, the quality assessment over the shelf life of the products obtained via internet has implications for the safety and efficacy of the drugs, and this should be considered by health professionals to safeguard the treatment of patients.

Estudo comparativo in vitro e avaliação da qualidade físico-química do antirretroviral aciclovir comprimidos obtidos via internet