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Psoriasis is a common immune-mediated chronic inflammatory disease that affects approximately 2~3% of the worldwide population. One of the pathogeneses of psoriasis is genetic components, and many genes are associated with it, but it is unclear how those genes work together [1]. Over recent years, there have been great advances on T cells and their roles in the inflammatory and autoimmune diseases that help us understand more deeply the pathogenesis of psoriasis. These immune cells move from the dermis to the epidermis and secrete inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-17 (IL-17) and interleukin-22 (IL-22). These secreted inflammatory signals stimulate the keratinocytes to proliferate and differentiate. Understanding these signaling pathways have led to the development of biologic agents that target cytokines and are now being used in clinical practice [2,3]. Some of the psoriasis signaling processes has been known through studies using the psoriasis skin model. Currently, researchers are continuously studying the pathogenesis of disease and therapeutic targets by reproducing the disease by in vitro and in vivo psoriasis skin model [4,5]. Here, we review the various current psoriasis skin models and summarize the advantages, disadvantages and suitability for describing certain aspects of psoriasis.

Psoriasis Skin Models as Promising Tools in Psoriasis Research