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The weight loss and muscle mass loss with consequent dysfunction of skeletal muscle are comorbidities that are frequently found in patients with chronic obstructive pulmonary disease (COPD). Dysfunction of skeletal muscles increases dyspnea and reduces exercise tolerance in patients with COPD Aim: determining the presence of weight loss and muscle mass loss, skeletal muscle dysfunction in patients with COPD, and the analysis in relation to the degree of COPD severity. Methods: 85 patients with stabile COPD were analyzed. The assessment of nutritional status was determined by body mass index (BMI) and skinfold thickness (TSF), and mid-upper arm circumference (MUAC) was used for assessment of muscle mass. For the assessment of dysfunction of skeletal muscles a 6-minute wallking test (6MWT), Borg scale and modified MRC (mMRC) scale of dyspnea were used. Results: BMI levels, MUAC and TSF decreased without statistical significance with increasing COPD severity. With the increase in COPD severity 6MWT significantly declined (p = 0.000), and Borg scale values before and after the 6MWT increased (p = 0.000), as well as the values of mMRC (p = 0.000). Severity of the disease in the whole group of patients had a significant negative correlation Original Research Respiratio

Disfunkcija skeletnih mišića kod obolelih od hronične opstruktivne bolesti pluća