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Portugal is the Western European country with the highest incidence rate of cervical cancer. Its main cause is the human papillomavirus (HPV) infection, and the most common method for its prevention and detection is the conventional and/or liquid-based cervicovaginal cytology. Conventional cytological smears have more disadvantages than the liquid-based ones; nevertheless, when it comes to glandular lesions, both the conventional and the liquid-based cytology present some limitations. This paper is about a 31 year-old woman whose results of the cytological screening tests differed from those of the histological ones. With the publication of the present work, we aim to highlight the limitations of the conventional smear when compared to the liquid-based cytology for the diagnosis of glandular lesions. Key-words: conventional cytology, liquid-based cytology, high-grade squamous intraepithelial lesion, glandular involvement, HPV Citotech Online – Case Review

Squamous lesions with glandular involvement: conventional cytology versus liquid-based cytology