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Inactivation of N-terminal acetyltransferase A is found to alter Rpn4 as well as E3 ligase abundance, causing up-regulation of Ubiquitin–proteasome activity. In this context, Tom1 is also identified as a novel chain-elongating enzyme of the UFD-pathway.

Up-regulation of ubiquitin–proteasome activity upon loss of NatA-dependent N-terminal acetylation