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This study reveals that the synaptonemal complex protein SYCE2 potentiates ataxia telangiectasia mutated–mediated DNA double-strand break repair by dissociating HP1α from trimethylated histone H3 lysine 9 in somatic cells.

Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair