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Abstract  Background: Rheumatoid arthritis (RA) is the most common inflammatory arthritis in the world. Its exact cause is unknown; proinflammatory and anti inflammatory cytokines play key roles in the pathophysiology of disease. Objectives: This study aimed to measure the level of pro inflammatory cytokines Osteopontin (OPN) and interleukin (IL-17) and anti-inflammatory cytokine interleukin 10 (IL-10) in study volunteers.  Materials and Methods: A case control hospital based study for groups of 88 rheumatoid arthritis patients was included from Outpatient Clinic. The control groups matched in numbers, age and sex with case. After inform consent, Serum from Both patients and controls were examined for OPN, IL-17 and IL-10.  Results: The mean age of RA patients was 41.0 ±11.7 years. 84 (95.5%) were females and 4 (4.5%) males. As well as 59 (67%) were anti CCP positive and others 29 (33%) were negative. No significant difference in OPN, IL-10 and IL-17 among patients gender. No statistic significant for OPN, IL-17 and IL-10 According to anti CCP. There were significant differences in OPN and IL-10, with mean (38.3±29.6, 45.9±42.9); respectively and (p-value 0.00) for each one. IL-17 exhibited no significant difference among case and control group.  Conclusion: The result indicate that there, is a significant increase of OPN and IL-10 in Rheumatoid arthritis Sudanese patients, moreover no significant in IL-17.

Expression of Osteopontin, Interleukin 17 and Interleukin 10 among Rheumatoid Arthritis Sudanese Patients