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Neuroendocrine tumors (NET) that develop at the second portion of the duodenum are rare, although most of NET at the duodenum is the first portion. We resected a duodenal NET by using a laparoscopic and endoscopic cooperative surgery (LECS) technique. A 33-year-old man underwent esophagogastroduodenoscopy that revealed a 6 mm, gently raising tumor on the opposite side of the ampulla of vater at the second portion of the duodenum. We performed a full-thickness local excision using the LECS technique. The tumor was confirmed and endoscopically marked along the resection line. After a full-thickness excision, using endoscopic and laparoscopy, closure using a liner stapler was performed laparoscopically. We demonstrated that LECS is a safe and feasible procedure for duodenal G1 NET at the second portion of the duodenum.

Successful Laparoscopic and Endoscopic Cooperative Surgery for a Duodenal Neuroendocrine Tumor: A Case Report