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Orthodontic treatment in diabetic patients is usually associated with periodontal disease and bone loss. Proinflammatory tumor necrosis factor-alpha (TNF-a) level increases in the periodontal tissue during orthodontic treatment. The aim of this study was to investigate the effect of infliximab (tumor necrosis factor-a antagonist) local injection on orthodontic tooth movement in diabetic rabbits. Methods: diabetes was induced in 22 male adult rabbit using Alloxan intravenous injection(100mg/kg). The level of blood glucose was controlled using subcutaneous insulin injection(0.5 IU/Kg Body weight). An orthodontic appliance was placed on the upper central incisors of all rabbits for 18 days to create a space between the two teeth. The rabbits were divided into two equal groups, the experimental group received 5mg/kg subperiosteal injection of tumor necrosis factor-alpha antagonist (infliximab)in the labial side of the upper central incisors in three time intervals (0,7,13 days )of the study period. The control group received equivalent volume of normal saline in the same location and same time intervals as experimental group. Clinical measurement of the created space were done in(5, 9,13, 18 )days of the studying period . Results: There was a significantly smaller rate of tooth movement in experimental group than control group represented by smaller spaces created. Conclusions: local injection of infliximab decrease the movement of the tooth during orthodontic treatment in experimentally induced diabetic rabbits.

The Role of Infliximab Local Injection on Orthodontic Tooth Movement in Experimentally Induced Diabetic Rabbits”