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Present research work aimed to develop a High-Performance Liquid Chromatography method for the estimation of selected antiviral agents like abacavir, dolutegravir and lamivudine in bulk and its formulation. Ascentis C18 150 x 4.6 mm, 3.7m column was used. Photodiode array detector was used to detect the analytes. Mobile phase containing Water: Methanol (60:40) was pumped at a low rate of 0.8 ml/min was selected. The retention time of abacavir, dolutegravir and lamivudine were 2.112 min, 2.545 min and 3.254 min. The linearity was obtained from 75-450μg/ml for abacavir, 6.25-37.5μg/ml for dolutegravir and 37.5-225 μg/ml for lamivudine. Precision studies were carried, and the%RSDwas found to be less than 2% for three drugs. The percentageof drug recoverywas goodwith thedevelopedmethod. Thedeveloped method was statistically validated according to the International Council on Harmonization guidelines. All the validation parameterswere performed, and the results were present within the acceptance limit. The stability-indicating studies were conducted under various stress conditions. Degradants did not interferewith the retention timeof the analyte andwere presentwithin acceptance criteria. The currentmethodwas economical and rapidwhen compared to past reported works.

international journal of research in pharmaceutical sciences

Simultaneous stability indicating HPLC method development and validation for the estimation of selected antiviral agents in bulk and Pharmaceutical Formulation