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Parkinson’s disease (PD) is a neurodegenerative disorder. It is characterized by a loss in substantianigra and striatum of dopaminergic neurons. The present study is to measure the antioxidant activity of chrysin and to assess behaviour in MPTP mice model of Parkinson’s disease. Male C57BL/6J mice divided into six groups (n=9). Different concentration (50, 100, 200 mg/kg) of chrysin was administered for ive consecutive days, MPTP administered 80 mg/kg (2 X 40 mg/kg 16 h interval) via intraperitoneal. After 48 hours of MPTP injection, a behavioural assessment was performed. After behavioural analysis, animals were sacri iced, and brains were collected. Collected brains were subjected for the analysis of Molecular studies, Biochemistry and Histopathology. Chrysin increased Glutathione peroxidase and Nitric oxide activity compared to MPTP induced mice. Similarly, when compared with the MPTP treated group, TRX 1 also increased in chrysin treated (100 and 200mg/kg) groups. It shows chrysin’s antioxidant scavenging activity, and thesemodi ications lead tomajor behavioural changes inmice treated with chrysin, these results being comparable with standard drug L-Dopa. All the groups were compared with the control groups.

Chrysin exerts anti-oxidant properties and restores motor function in MPTP induced mouse model of Parkinson disease