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The goal of the research was to assess the antiurolithiatic property of Carissa carandas Linn. leaf extract in rats. The rats were segregated into 6 groups of 6 rats each. Calcium oxalate urolithiasis was surgically incited by insertions of pre-weighed and sterile zinc disc in bladders of animals. This was also followed by supplementing 0.75% v/v ethane-1, 2-diol (Ethylene glycol) in quaf ing water ad libitum for 28 days. Upon postsurgical recovery period (3 days), Cystone (750 mg/kg) and three doses of EELCC (Ethanolic extract of leaves of Carissa carandas Linn.) namely 100, 200, and 400 mg/kg b.w., were given to zinc disc inserted animals for the duration of 28 days by oral route. Antiurolithiatic property was assessed by measuring the urinary volume, weight of the calculi, estimating the pH and analyzing the proportion of diverse biological markers in urine and serum specimens. An outstanding reduction in urine output and pH were noticed in zinc disc inserted rats, which were intercepted by the remedial extract. The extract also produced a signi icant enhancement in rate of glomerular iltration (GFR) and reduced the calculi deposition throughout the inserted zinc disc. The elevated levels of serum and urinary biochemical parameters like creatinine, urea, calcium, blood urea nitrogen (BUN), oxalate, and uric acid were also prevented by the extract. A signi icant (P< 0.01) potential antiurolithiatic property is observed at 400 mg/kg of EELCC.

international journal of research in pharmaceutical sciences

Assessment of potential antiurolithiatic property of Carissa carandas Linn. leaves on zinc disc insertion - incited urolithiasis in wistar male albino rats