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Membrane lipid peroxidation and DNA, protein damage is mediated by free radicals,which formthebasis of chronicpathological complications.AgNPsare an important class of nanomaterials for a wide range of biomedical applications. Thepresent studyendeavors in vitro antioxidant andanti-in lammatory activity of green synthesized silver nanoparticles (AgNPs) using medicinal plant extract from Caesalpinia bonducella seeds. Total lavonoid and phenolic contents were determined. The antioxidant potential of capped AgNPswas assessed using DPPH assay, Phosphomolybdenum assay, FRAP assay, metal chelating, hydrogen peroxide, and hydroxyl radical scavenging methods. In vitro anti-in lammatory assay of CB seed, AgNPs were performed against the standard drug. CB seedAgNPs possessed high lavonoid and phenol compared to aqueous CB seed extract. The antioxidantmethods con irmed that the silver nanoparticles have more antioxidant activity as compared to vitamin C. The synthesized silver nanoparticles exhibited potential anti-in lammatory activity with the IC50 71.3μg/ml. Hence, this work clearly demonstrated that the coated AgNPs with CB seeds act as a potent free radical scavenger and could be considered as a potential source for anti-in lammatory drugs.

Assessment of in vitro Antioxidative and Anti-Inflammatory Effect of Caesalpinia Bonducella Seed Stabilized Silver Nanoparticles