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NEUROPATHY DETECTION, QUALITY OF LIFE TOOLS & TREATMENT FOR TYPE 2 DIABETES Jennifer J. Brown Old Dominion University, 2016 Director: Dr. Sheri Colberg-Ochs Type 2 diabetes (T2D) mellitus has become the epidemic of the new millennium, with an estimated 382 million people affected worldwide as of 2013, and statistics projected towards 592 million by the year 2035. With the development of diabetes, complications have risen, with diabetic neuropathy becoming one of the most prevalent, affecting between 10–90% of those with the disease. Diabetic peripheral neuropathy (DPN) is difficult to detect in early stages of pathology, yet devastating once significant damage has taken place. Cardiac autonomic neuropathy (CAN), which is often silent, is associated with autonomic nervous system (ANS) dysfunction and increased risk for sudden death. Therefore, the purposes of this dissertation were early detection, assessment of quality of life (QOL) and disease intervention. Study I explored the effectiveness of the 128-Hz tuning fork, the 1-g and 10-g monofilaments, and the QOL-DN as tools for the early detection of DPN in overweight, obese and inactive (OOI), prediabetes (PD), and type 2 diabetes (T2D) individuals. Study II compared three QOL assessments: the QOL-DN, the PN-QOL-97 and the NeuroQOL-28, in OOI, PD and T2D individuals. Study III involved the execution of a double blinded, placebo controlled exploration of melatonin as a potential intervention for the improvement of ANS and sleep dysfunction in T2D. The results of Study I suggest that the 1-g monofilament and QOL-DN measures correlate to NC-Stat DPN Check portable nerve conduction study (NCS) findings, that these

Neuropathy Detection, Quality of Life Tools & Treatment for Type 2 Diabetes