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iv Introduction  1 Electronic Cigarette Models  2 ECIG Liquid Solutions  4 ECIG Use Patterns and Reasons for Use  9 Regulation: Tobacco Control Act  11 What Do ECIGs Do: Nicotine Delivery  12 Puff Topography  18 ECIGs Nicotine Delivery: Implications for Various Populations....  22 Need for Systematic ECIG Evaluation  25 Statement of the Problem  26 The Present Study  27 Statement of the Hypothesis  27 Method  27 Selection of Participants  27 Screening and Informed Consent Procedures  33 Materials  33

Electronic Cigarette User Plasma Nicotine Concentration and Puff Topography: Influence of Liquid Nicotine Concentration and User Experience