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INVESTIGATING THE ROLE OF BPTF IN IMMUNOEDITING IN BREAST CANCER AND MELANOMA by Kristen Nichole Peterson, B.S A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University Virginia Commonwealth University, 2015 Major Director: Joseph W. Landry Assistant Professor, Department of Human and Molecular Genetics In this study, we explore the effects of NURF depletion on the growth of tumors in immunecompetent mice. NURF depletion in tumors results in reduced tumor growth in immunecompetent mice, suggesting enhanced anti-tumor immunity. Analysis of the tumor microenvironment by flow cytometry revealed a significantly elevated CD8 and progressively elevated activated CD8 phenotype in Bptf KD tumors, possibly contributing to the increase in cell death and decrease in tumor weight observed. Examination of antigen presentation was evaluated using the OT-1 and Pmel-17 models, though no significant difference in cytotoxicity was observed as measured by LDH and/or IFNγ assays. This indicates possible novel antigen presentation mechanisms in tumor cells, and not increased presentation of existing antigens, contributes to the decreased tumor weight observed in Bptf KD tumors.

Investigating the Role of Bptf in Immunoediting in Breast Cancer and Melanoma