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The present work is a continuation of the previous studies on the rate of cell production in the thymolymphatic organs (0 so g o e et al ., 1957 ; Monde n, 1959a ; and I t o, 1959), and deals with the rate of mitotic activity in the bone marrow. Its principal objective is to estimate the total number of blood cells newly produced by mitosis per day in the bone marrow of young mature albino rats, and, using the previously reported data on total cellular numbers in the circulating blood and bone marrow of similar rats (M o n d e n, 1958b 'and A w a y a et al., 1960), to calculate the time taken for the replacement of a number of cells equal to that in the whole population (turnover time), with respect to each type of blood cells. It is a very difficult task to make quantitative approaches along this line. So far as the writer is aware, Kindred is the first who made a series of studies of this type, using rats as material (K in d r e d, 1938, 1940 and 1942). These studies are chiefly based on cell counts and mitotic counts of given areas in sections of the hematopoietic organs. It should be borne in mind, therefore, that the tedious histologic counting difficulties may cause uncertainty in the results, and that extrapolation of the results from cell counts in limited areas of sections to whole organ can be misleading. After K i n d r e d, only fragmentary information has, been reported concerning the quantitative aspects of cell production in the bone marrow.

A Quantitative Study on the Rate of Cell Production in the Bone Marrow of Young Mature Albino Rats.