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3 BACKGROUND 5 Objectives/Aims  8 PARTICIPATION OF PATIENTS AND OTHER STAKEHOLDERS  11 METHODS  13 Study Overview  13 Study Design  13 Participants  14 Intervention  14 Comparator  16 Study Outcomes and Data Collection  17 Study Setting  22 Time Frame for the Study  22 Analytical and Statistical Approaches 23 Protocol Changes  25 RESULTS  26 Recruitment  26 Baseline Demographics and Outcome Relationships  28 Primary Outcomes  43 Secondary Outcomes  47 Adverse Events 48 DISCUSSION  48 Context for Study Results  48 Generalizability of the Findings  50 Implementation of Study Results  51 Subpopulation Considerations 51 Study Limitations  52 Future Research  54 CONCLUSIONS  55 REFERENCES  56 RELATED PUBLICATIONS  64 ACKNOWLEDGMENTS  65 APPENDIX  66

Using a Program to Lower Stress for Caregivers of Patients With Cancer Who Have Received Stem Cell Transplants