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SCC is getting global attention for its increasing incidence in youngsters.1 On a universal ranking it is the 6th commonest malignancy.2 In Pakistan, it is the 2nd commonest cancer in individuals more than 15 years of age.3 In routine, approaches to diagnose OSCC include adequate clinical examination (CE) followed by histological investigation of suspicious sites but they are not efficient to diagnose OSCC at an earlier stage.4 Although, biopsy is considered as gold standard but it is a time consuming5 and site specific procedure.6 Other issue associated with incisional biopsy is increased chance of metastasis due to breakage in tissue barrier.7 In addition to it, high-risk areas with DNA mutation are not always evident on histopathology. So, these factors increase the need of more efficient diagnostic marker to prevent late and missed diagnosis of OSCC.8 Salivary detection of diseases has advantage of non-invasiveness, convenience and less discomfortness. These factors make saliva as an efficient medium for the detection of OSCC markers. Nosratzehi observed the levels of MMP1 and other MMPs in saliva of OSCC patients and came to a conclusion that further research is necessary to determine relation between MMPs and OSCC.9 MMP1 is a soluble type of interstitial collagenase responsible for the degradation of fibrillarcollagen-I, II and III.9 In 2016, salivary MMP1 was introduced in "Taiwan's 1. Co-ordinator, Department of Dentistry, Institute of Advanced Dental Sciences and Research (IADSR). 2. Head of Department, Department of Oral & Maxillofacial Surgery, Mayo Hospital, Lahore. 3. Medical Officer, Department of Oral & Maxillofacial Surgery, Mayo Hospital, Lahore. 4. Chairperson, Department of Dentistry, Institute of Advanced Dental Sciences and Research (IADSR). Corresponding author: “Dr. Sana Jafar Zaidi” < sanajaffar98@gmail.com >

Salivary Matrix Metalloproteinase (MMP)-1 as Non-Invasive Tool for The Diagnosis of Oral Squamous Cell Carcinoma (OSCC)