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Combination therapy using a diode laser and indocyanine green(ICG) was evaluated for the endoscopic treatment of gastrointestinal disease. Approximately 10ml of ICG solution with the 1mg/ml concentration was administrated to canine esophageal and colonic submucosa to enhance the tissue absorption for 805nm laser light. We performed the 25W diode laser intermitted radiation with ls duration until the mucosa was removed and the submucosa was exposed. In the case of esophagus, reliable irradiation was difficult owing to the narrow canal space and the heart beat. When the ablation reached to esophageal submucosa, thermal damage also occurred in the proper muscle. Coagulation with/without carbonization sometimes was induced by insufficient irradiation intensity. In this case the thermal damage also affected the proper muscle. We think by using the transparent food and decreasing the laser output, this method may be applicable for the treatment of esophageal cancer, Barret's esophagus and varices. In the case of the colon, the selective ablation and coagulation of the submucosa without proper muscle damage was obtained. This method might be useful for the vilous adenoma and carcinoid tumor as well as early colonic cancer. We think the diode laser therapy using ICG should be one of the useful alternatives for the gastrointestinal disease.

Combination therapy of diode laser irradiation and submuosal administration of indocyanine green solution.