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We have demonstrated that NPe6 accumulated in atheroma was detected from the adventitia of the artery using an epifluorescence microscopy. The evidence indicated that NPe6 was activated by laser irradiation from outside of the artery. In this study, we analysed the effects of laser irradiation to the atheroma pretreated with NPe6 from the adventitia of the aorta using a Fourier transform infrared (FTIR) microspectroscopy, FTIR spectrum analysis showed that the ester bond of cholesterol esters in atheromas was discarded after photodynamic treatment with no concomitant increase of free cholesterols. Photodynamic treatment with NPe6 could be effective to decrease the lipids in the atheroma. 緒 言 虚血性心疾患の発症母胎である冠動脈の粥状 動脈硬化病変部に対するレーザー応用として、 クロリン系光感受性物質NPe6を プローブに用 いた蛍光画像診断法を開発 した。本法の特徴は 血管外から照射 したレーザーにより、冠動脈の 粥状動脈硬化巣に選択的に集積 したNPe6を 励 起し、その蛍光を映像として把握できることを 示した点にある。このことはレーザー照射によ る組織フルエンスを治療域まで高めることで血 管外からでも粥状動脈硬化巣を治療できる可能 性があることを意味している。そこで今回、血

Fourier Transform Infrared Microspectroscopy Analysis for Chemical Components in Atheroma after Photodynamic Treatment