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Photodynamic therapy(PDT) of cancer has been improved by the developments of laser technology and photosensitizers. However, we need a new sensitizer because of selective cancer therapy. PH-1126 was a derivative of pheophorbide-a and produced by Hamari Chemical Ltd..In present study, we investigated the effect of liposome for PH-1126 distribution in C3H mice. In the results, the concentration of PH-1126/tartarate in tumor increased 38hrs after the intravascular injection and then gradually decreased. In contrast, the concentration of PH-1126/liposome in tumor increased 24hr after injection and about thirty times larger than PH-1126/tatarate. It is considered that PH-1126/liposome can be a useful sensitizer of PDT.

Distribution of PH-1126/liposome in C3H mice