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we experimentally and clinically assessed the accumulation of doxycycline in arteriosclerotic lesions by fluorescence microscopy and fluorescence spectrum analysis. In the experimental study using spectral analysis, we observed autofluorescence of the media the intimal thickening was less than 100 ti m and its peak at 540 nm. we also observed mixed fluorescence spectral patten of doxycycline fluorescence peak at 560nm and media autofluorescence of 540nm peak. In contrast, when intimal thickening was 100 tt m or more, we observed only doxycycline fluorescence peak at 560nm. In the clinical study, doxycycline fluorescence (peak at 560nm) was observed at sites of coronary artery stenosis, and the intensity of this fluorescence was significantly higher than at normal sites . Sinece yellowish green doxycycline fluorescence was observed by fluorescence microscopy of DCA tissue obtained from angina patients treated with thin agent, doxycycline obviously accumulates in the arteriosclerotic lesions of human coronary arteries in vivo. This method appears capable of being applied to intraoperative monitoring of the PTLCA, DCA, etc , as well as to PDT.

Assessment of the Clinical Application of Doxycycline Fluorescence in the Coronary Arteries and its Accumulation in Resected DCA Tissue