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We experimentally evaluated an adaptability of a pulsed Ho:YAG laser for the treatment of urinary tract strictures. The pulsed Ho:YAG laser (fluence:160J/cm2) was used to ablate canine ureter, comparing to a continuous ultraviolet argon (UV Ar) laser(intensity:from 400W/cm2 to 1600W/cm2). The individual laser beams were delivered through a silica glass fiber (0.4mm in core diameter) and vertically irradiated to the canine ureter at the various durations. The ablated ureters were histologically examined and the ablation depths were measured. The ureter wall was sharply ablated by both Ho:YAG laser and UV Ar laser. The thickness of thermally damaged layer by Ho:YAG laser ablation was slightly thinner than by UV Ar laser ablation. However, the Ho:YAG laser ablation efficiency (3.7X10+0.6-5g/J) was smaller than the UV AR laser ablation efficiency (16.7X10+9.5-5g/J). We demonstrated that the both laser ablation was useful for the laser treatment of the urinary tract stricture.

The basic study of ureteral stricture treatment using Ho:YAG laser: