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To evaluate the electrical potential decrease in an in vivo animal myocardial model by oxidation induced by an extracellular photosensitization reaction using talaporfin sodium, the authors studied an in vitro myocardial cell model that has an irrigation system that improves the oxygen supply. To perform this evaluation, the authors compared the in vivo and in vitro models using a new metric to measure the electrophysiological effect on the myocardium/myocardial cells by a photosensitization reaction. The electrical potential in the myocardium on the inside surface of a canine superior vena cava of the in vivo model was measured by a multielectrode ring catheter. In the in vitro model, the spontaneous action potential waveforms were measured using a voltagesensitive dye. The model used a flowing talaporfin sodium solution—at a rate of approximately three replacements per second— to improve the oxygen supply in the area of the photosensitization reaction. A new metric—the radiant exposure required to decrease the electrophysiological signal to 1/e of its initial value—was used to compare the electrophysiological effects on 〒 223-8522 神奈川県横浜市港北区日吉 3-14-1 TEL: 045-563-1151(内線 42580) (3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan) Corresponding author: m.doi@arai.appi.keio.ac.jp(土井万理香) JJSLSM Vol.39 No.4 (2019) 303

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Comparison of an <i>in vivo</i> Model with an <i>in vitro</i> Model Based on the Electrical Potential Decrease in the Myocardium or Myocardial Cells by an Extracellular Photosensitization Reaction

Comparison of an in vivo Model with an in vitro Model Based on the Electrical Potential Decrease in the Myocardium or Myocardial Cells by an Extracellular Photosensitization Reaction