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We demonstrated the anti-inflammatory effect of daily external low-reactive level laser irradiation (LLLI) in an animal model of crescentic glomerulonephritis. Crescentic glomerulonephritis was induced in rats by intravenous injection of antibody for glomerular basement membrane (GBM). The rats were irradiated with a low-reactive level diode laser with an infrared wavelength of 830 nm from the shaved skin surface once a day for 14 days (irradiation spot size on the skin surface, 2.27 cm2; power intensity, 880 mW/cm2; irradiation mode, continuous mode; irradiation time, 250 s; energy, 500 J; energy density, 220 J/cm2). After laser irradiation for 14 days, the kidneys were taken, and the extent of inflammation was evaluated. LLLI showed anti-inflammatory effect on the renal tissue.

Low-reactive Level Near-infrared Laser Irradiation Suppresses Glomerulonephritis in Rats