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Objectives: This randomized study aimed to compare the efficacy of intraoperative versus postoperative paracetamol on postoperative nausea and vomiting (PONV) in morbidly obese paitients undergoing laparascopic bariatric surgery. Methods: Sixty patients were randomly divided into tow equal groups (n=30). In the intraoperative paracetamol group, patients received intravenous (IV) infusion of paracetamol 1000 mg during anesthesia, but before surgery In the postoperative paracetamol group, patients received IV infusion of paracetamol 1000-2000 mg in the recovery room. Postoperative pain condition was evaluated using the Faces Pain Scale. In the recovery room, an observer recorded the pain score, complaints of nausea and vomiting, the need for rescue analgesics, and the need for antiemetic drug during 24 h postoperatively. Results: The incidence of nausea and vomiting during the first 24 h postoperatively was significantly lower in the intraoperative paracetamol group than in the postoperative paracetamol group (p=0.05). Conclusion: The intraoperative administration of paracetamol reduces PONV incidence in morbidly obese paitients undergoing laparascopic bariatric surgery.

bìlʹ, znebolûvannâ ì ìntensivna terapìâ

Effect of intravenous intraoperative versus posoperative paracetamol on postoperative nausea and vomiting in patients with morbid obesity undergoing laparoscopic bariatric surgery