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In this paper we proposed a novel classiflcation system to distinguish among elderly subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and normal controls (NC). The method employed the magnetic resonance imaging (MRI) data of 178 subjects consisting of 97NCs, 57MCIs, and 24ADs. First, all these three dimensional (3D) MRI images were preprocessed with atlas-registered normalization. Then, gray matter images were extracted and the 3D images were under-sampled. Afterwards, principle component analysis was applied for feature extraction. In total, 20 principal components (PC) were extracted from 3D MRI data using singular value decomposition (SVD) algorithm, and 2 PCs were extracted from additional information (consisting of demographics, clinical examination, and derived anatomic volumes) using alternating least squares (ALS). On the basic of the 22 features, we constructed a kernel support vector machine decision tree (kSVM-DT). The error penalty parameter C and kernel parameter ae were determined by Particle Swarm Optimization (PSO). The weights ! and biases b were still obtained by quadratic programming method. 5-fold cross validation was employed to obtain the out-of-sample estimate. The results show that the proposed kSVM-DT achieves 80% classiflcation accuracy, better than 74% of the method without kernel. Besides, the PSO exceeds the random selection method in choosing the parameters of the classifler. The computation time to predict a new patient is only 0.022s.

CLASSIFICATION OF ALZHEIMER DISEASE BASED ON STRUCTURAL MAGNETIC RESONANCE IMAGING BY KERNEL SUPPORT VECTOR MACHINE DECISION TREE