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Cancer is a non-communicable disease that causes morbidity and mortality in all regions of the world. One of the cancer treatments is using the chemotherapy drug cisplatin, but cisplatin has toxic side effects if consumed in certain doses and times. The combination of bovine serum albumin (BSA) nanoparticles containing cisplatin was developed with binding modification using folic acid as an alternative solution to minimize the resulting toxic effects and optimize the drug delivery system. The research objectives were the synthesis of combined nanoparticles (BSA) containing cisplatin and modification of the bonds using folic acid as an anticancer candidate. This research was conducted through synthesis with the desolvation method. The results showed that the bovine serum albumin nanoparticles combined with cisplatin and folic acid were successfully synthesized. FT-IR analysis showed that the O-H functional groups of alcohol, C-H, C-C, NO2 play a role in the synthesis of nanoparticles. XRD analysis shows that there is a peak shift from NP-BSA 31.69 and As-CP-NP-BSA 34.45. The size of NP-BSA nanoparticles was 2.38 nm and As-CP-NP-BSA 2.62 nm while SEM-EDX analysis of the elements of C, O, Mg, Cl and Pt.

Sintesis Nanopartikel Bovine Serum Albumin Kombinasi Cisplatin dan Asam Folat Sebagai Kandidat Antikanker