Open AccessSevere acute respiratory syndrome coronavirus 2: Mutations and variants of concern – the Indian scenario
Author(s) -
HS Darling,
Purvish M. Parikh,
Radhika Vaishnav,
Amit Verma,
Ashish Gulia,
Akhil Kapoor,
Randeep Singh
Publication year - 2021
Publication title -
international journal of molecular and immuno oncology
Language(s) - English
Resource type - Journals
eISSN - 2836-3779
pISSN - 2456-3994
DOI - 10.25259/ijmio_14_2021
Subject(s) - pandemic , coronavirus , virulence , covid-19 , virology , pathogenicity , disease , virus , transmissibility (structural dynamics) , biology , medicine , gene , genetics , microbiology and biotechnology , infectious disease (medical specialty) , vibration , quantum mechanics , vibration isolation , physics
When India did well to contain the first wave of coronavirus disease 2019 (COVID-19) pandemic, none of us had an inkling of the magnitude that the second wave was going to take. One of the main reasons for the resurgence is several new mutants of this virus – the important ones for our country being UK Variant, Indian Double mutant, South African, and Brazil variants. Questions regarding their impact on virulence, pathogenicity, transmissibility, detection, clinical symptomatology, morbidity, mortality, potential curability, and possibly decreased therapeutic/ vaccine efficacy are being ascertained. We hereby summarize the importance of these variants with respect to Indian scenario, with emphasis on implications regarding COVID-19 diagnosis and efficacy of current vaccines.
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