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The antifungal therapy combined is used in clinical practice of several mycoses as it may increase the efficacy of thetreatment. The use of natural products (phytochemicals) in combination with conventional antifungal drugs has been relatedto beneficial effects, mainly synergistic effects. The aim of this study was to evaluate the effect of the combined use ofeugenol / isoeugenol, compounds with recognized antimicrobial activity, in association with antifungal amphotericin Bagainst strains of Cryptococcus neoformans. The combined antifungal effect were be determined from the FractionInhibitory Concentration index - checkerboard technique. The results obtained in this study showed that eugenol incombination with amphotericin B had antagonistic effect against the strains of C. neoformans, LM 615 and INCQS 40221(FIC index 6.0 and 4.0), respectively. The combination of the isoeugenol and amphotericin B also showed antagonisticeffects for both the LM 615 strain and INCQS 40221 (FIC index 6.0 and 5.0), respectively. This study contributed to theunderstanding of the antifungal effects of the association of phenylpropanoids (eugenol / isoeugenol) with amphotericin B.Further studies are needed to evaluate and compare the effects of the association of these phytochemicals with otherconventional antifungal drugs used against C. neoformans.

Eugenol and Isoeugenol In Association with Antifungal Against Cryptococcus neoformans