Concept of Polycystic Ovarian Syndrome: Perspectives of Ayurveda and Modern Science

Non enzymatic glycation is a chain reaction between reducing sugars and the free amino groups of proteins, involved inseverity of diabetes and diabetic complications. Litchi chinensis used as consumed fruit and as a drug to treat certaindiseases. In this study the antioxidative effects of L.chinensis and also its effect against protein oxidation and advancedglycation end products. The antioxidant potential of aqueous fruit pericarp extract of L.chinensis (APLC) was evaluatedin vitro using a model of fructose-mediated protein glycation. The antioxidant activity of APLC conducted forsuperoxide, hydroxyl, hydrogen peroxide, nitric oxide radical scavenging activities and also demonstrated antioxidantactivity with Fe+2 chelating activity, ferric reducing antioxidant power (FRAP) and Trolox equivalent antioxidantcapacity (TEAC) were applied. Fructose (100mM) increased fluorescence intensity of glycated bovine serum albumin(BSA) in terms of total AGEs during 21 days of exposure. Moreover, fructose caused more protein carbonyl (PCO)formation in native BSA. The APLC prevents oxidative protein damages including effect on PCO formation which arebelieved to form under the glycoxidation process. The APLC at different concentrations (25-250µg/ml) has significantlydecreased the formation of AGEs in term of the fluorescence intensity of glycated BSA.