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A rhizome of Zingiber officinale R. commonly known as Ginger is one of the most popular anti-inflammatory drug in Indian traditional medicine. 6-gingerol is one of the constituent contributing in anti-inflammatory activity of Ginger. Ginger extract and 6-gingerol act as an anti inflammatory via inhibition of proinflammatory cytokines. Increase in proinflammatory cytokines is also responsible for the reduction in food intake resulting anorexia. The aim of the present study was thus to determine antianorectic activity of standardized hydroalcoholic extract of ginger and similarly the biomarker 6gingerol was also studied to evaluate its contribution in antianorectic activity. Anorexia was induced by intraperitoneal administration of E.coli lipopolysaccharide (100μg/kg) and Fluoxetine (FLU 8mg/kg) in rats. The effect of same doses of the extract was also tested in freely feeding rats. Effect of ginger and 6gingerol both were studied The results showed that at 200 and 400 mg/kg, ginger reversed the anorectic effect while 6gingerol at 5mg/ kg require for the effect. Moreover the same doses did not modify the food intake in freely feeding rats. These findings provide strong evidence that ginger is able to attenuate anorexia induced by proinflammatory cytokines mediators.

Evaluation of Anti Anorectic Activity of Zingiber officinale R. (Zingiberaceae)