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The objective of the current study was led to reveal the possible protective effects of n-butanol extract of Helianthemumconfertum (H. confertum) against doxorubicin (DOX) induced liver damage and its implication on the integrity of livercells. Adult male rats were randomly divided into groups treated with plant extract (50 mg/kg, 100 mg/kg) for 10 daysand/or injected with a single dose of DOX (10 mg/kg). Liver function as well as oxidative stress parameters and histologicalstudy were estimated. DOX treated rat’s induced hepatic dysfunction revealed by a significant increase in biochemicalparameters (serum transaminases, cholesterol and triglycerides) and disturbance in oxidative stress parameters describedby an increase in malondialdehyde (MDA) levels, providing information on the loss of cellular integrity. This later elicitedhistopathological changes in the liver which was confirmed on histological section chowing necrotic cells. Altghout theDOX-treatment reduced significantly the reduced glutathione (GSH) level and the glutathione peroxidase (GPx) activity.The pretreatment of the animals with n-butanol extract of H. confertumat 50 mg/kg and 100 mg/kg counteracted almost alladverse effects induced by DOX. The results showed a considerable decrease in serum markers of liver function and lipidperoxides. There was significant increase in the GSH level and the activity of antioxidant enzyme (GPx), which allowedthe normalization of redox status in liver cells. Data suggest that DOX-induced an oxidative stress in rat’s liver and nbutanolextract of H. confertum exerted antioxidant properties.

international journal of pharmacognosy and phytochemical research

Chemoprotective Potential of Helianthemum confertum Against the Loss of Molecular and Functional Integrity of the Liver Cell in Doxorubicin-Treated Rats