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The interactions of drug amoxicillin with maltose or galactose solutions with a variation of temperature have been discussed by taking in the volumetric and viscometric procedures. Physical properties [densities (ρ) and viscosities (η)] of amoxicillin (AMOX) aqueous solutions and aqueous solutions of two type saccharides (maltose and galactose 0.05m) have been measured at T = (298.15, 303.15 and 308.15) K under atmospheric pressure. The apparent molar volume (φv cm3mole-1) has been evaluated from density data and fitted to a Redlich-Mayer equation. The empirical parameters of the Mayer-Redlich equation and apparent molar volume at infinite dilution Ø°v were explicated in terms of interactions from type solute-solvent and solute–solute interactions. Transfer molar volume ΔtraØ°v for AMOX from water to aqueous maltose and galactose solutions were calculated to comprehend different interactions in the ternary solutions. Limiting apparent molar expansibility (Ø°E) and Hepler’s coefficient was also calculated to indicate the structure making ability of AMOX in the ternary solutions. Jones–Dole coefficient B and A have been calculated from viscosity data by employing the Jones–Dole equation. The free energy of activation of viscous flow per mole of the solute (Δμ°2*) and solvent (Δμ°1*) have been explained on the basis of the Eyring and Feakins equation. Keyword: Amoxicillin, Apparent molar volume, Jones–Dole equation, Redlich-Mayer equation, Saccharide. International Journal of Drug Delivery Technology (2020); DOI: 10.25258/ijddt.10.1.30 How to cite this article: Merza SH, Abood NH, Abbas AM. Study of molecular interaction for antibiotic drug with sugar solutions at different temperature. International Journal of Drug Delivery Technology. 2020;10(1):170-174. Source of support: Nil. Conflict of interest: None Study of Molecular Interaction for Antibiotic Drug with Sugar Solutions at Different Temperature Sundus H. Merza*1, Nagham H. Abood2, Ahamed M. Abbas1 1Department of Chemistry, College of Education for Pure Science /Ibn-Al-Haitham, University of Baghdad, Baghdad, Iraq 2Department of Applied science, Applied Chemistry, University of Technology, Baghdad, Iraq Received: 21th Dec, 19; Revised: 23th Jan, 20, Accepted: 12th Feb, 20; Available Online: 25th Mar, 2020