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Erythromelalgia is a rare condition that may be associated with a variety of underlying conditions and can be refractory to therapy. We report a case of a patient with mast cell activation syndrome (MCAS) who developed erythromelalgia and responded to low dose naltrexone (LDN).

Erythromelalgia in a Patient with Mast Cell Activation Syndrome: Response to Low Dose Naltrexone