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The computational methods to detect the coding regions of genes and specific sequences of the transcriptional control region using stochastic models such as the hidden Markov Model have been developed. But there are still aspects of the control of the gene expression based on a sequence of the transcriptional control region that have not been described. We report here our attempt to apply texture analysis to a sequence surrounding a transcriptional starting site to extract the features. We developed the features extraction program by employing texture analysis based on the gray level run length matrix and applied it to sequences surrounding transcriptional starting sites of genes coding the heat shock proteins. Thus we could successfully represent features extracted from a sequence surrounding transcriptional starting sites as specific patterns of them.

seibutsu kankyō chōsetsu/seibutsu kankyou chousetsu

Pattern Extraction from a Sequence Surrounding a Transcriptional Starting Site Using Texture Analysis: The Utility of Texture Analysis Based on the Gray Level Run Length Matrix