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To analyze clinical effect and safety of paroxetine and sertraline hydrochloride used for depression treatment after cerebral stroke, 58 patients with depression after cerebral stroke were chosen as the objects of study, and they were divided into two groups at random according to the numeration table. 29 patients in the control group were treated with paroxetine, while the 29 patients in the experimental group were treated with sertraline hydrochloride. Clinical effects and safety of both groups were compared and summarized. Results show that, before treatment, Self-rating Anxiety Scale (SAS) score and Self-rating Depression Scale (SDS) score of both groups had no statistical significance (p>0.05). After the treatment for 2w, 5w and 7w, negative mood improved significantly, and score difference of both groups at two points in time after the treatment had no statistical significance (p>0.05). But according to adverse effects of both groups, the total occurrence rate of adverse effects in experimental group was obviously lower than that of the control group, and the difference had statistical significance (P<0.05). Thus, it can be concluded that both paroxetine and sertraline hydrochloride can gain the ideal effect when being used to treat depression after cerebral stroke, and they contribute to improving patients’ negative mood. But by contrast, adverse effects of sertraline hydrochloride are fewer, which indicates its safety is higher and deserves to be promoted and applied clinically.

Clinical Effect and Safety Evaluation of Paroxetine and Sertraline Hydrochloride Used for Depression Treatment after Cerebral Stroke