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Objective: To investigate the frequency of anemia and its association with inflammation in patients with subacute thyroiditis (ST) during diagnosis and after the resolution of clinical findings and acute-phase response. Materials and Methods: We retrospectively reviewed the charts of patients with confirmed diagnosis of ST, followed at the Endocrinology and Metabolism Outpatient Clinic of Istanbul Faculty of Medicine (Turkey). The study cohort comprised those with acute-phase response and hemogram results during diagnosis and after the resolution of clinical and inflammation findings. Hemoglobin levels of <12 and <13 g/dl for females and males, respectively, were defined as anemia. Results: Anemia was detected in 37 of 60 ST patients (65%) studied during diagnosis, and its frequency reduced to 28.3% following the resolution of clinical and laboratory findings without additional treatment. Notably, although a significant increase was observed in terms of hemoglobin (1.08 ± 0.98 g/dl) and hematocrit (3.45 ± 2.9) levels, no change was detected in terms of MCV values. During diagnosis and following the clinical improvement, hemoglobin and hematocrit values of 20 patients (33.3%) who developed permanent hypothyroidism following the resolution of clinical findings were significantly lower than those of the remaining patients. Conclusion: Anemia can develop in 65% of patients with ST. A significant improvement can be observed following resolution of clinical and laboratory findings. Therefore, further studies investigating the causes of anemia should be avoided in patients with ST until clinical findings and acute-phase response have been improved.

Frequency of Anemia and Its Association with Disease Activity in Subacute Thyroiditis