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Using the circular nature of the 16kbase-pairs human mtDNA genome, we are looking for hypothetical proportions between the C + A and T + G bases. Remarkable proportions are thus discovered, the length of which may be much greater than the length of the genome. We then analyze the impact of evolution on these "numerical resonances" by comparing the referenced mtDNAs of Sapiens, Neanderthal and Denisova. Then, by analyzing 250 characteristic mutations associated with various pathologies, we establish a very strong formal causal correlation between these numerical metastructures and these referenced mutations. To summarize, we should think then research on the following situation: Inputs: 250 cases of mtDNA mutations associated with var ious human diseases. An operator: The exhaustive search for mtDNA genome " Fibonacci resonances" associated with these mutations. A "binary" output: a common behavior of the mtDNA genome resulting from these 250 mutations disor ders. INTRODUCTION Nearly 30 years ago, when we were just starting to have available genes and small genomes DNA sequences of viruses or bacteria, while the large project of human genome sequencing was just beginning, we showed the existence of specific numerical nucleotides proportions in the DNA of the genes (1, 2). This discovery also applied to small circular genomes such as those of bacteria or mitochondrial DNA genes-rich sequences. On the other hand, it did not work for non-coding DNA sequences regions like human chromosomes. In the cells, Mitochondria are known as the powerhouses of the cell. They are organelles that act like a digestive system which takes in nutrients, then breaks them down, and creates energy rich molecules for the cell. The biochemical processes of the cell are known like a « cellular respiration ». The genome of the mitochondria or "mtDNA" is a small 16kb genome whose remarkable feature is the fact that it is looped back on itself forming a circular sequence. This is also true of the genomes of most bacteria. As in prokaryotes, there is a very high proportion of coding DNA and an absence of repeats. It encodes 37 genes: 13 for subunits of respiratory complexes I, III, IV and V, 22 for mitochondrial tRNA (for the 20 standard amino acids, plus an extra gene for leucine and serine), and 2 for rRNA. One mitochondrion can contain two to ten copies of its DNA. Mitochondrial genomes have been extensively studied and identified, especially for many years by Douglas C. Wallace (3, 4, 5). This genome possesses the remarkable hereditary characteristic of being transmitted only SAPIENS MTDNA CIRCULAR LONG-RANGE NUMERICAL METASTRUCTURES ARE HIGHLY CORRELATED WITH MTDNA DISEASES MUTATIONS SDRP Journal of Cellular and Molecular Physiology

Sapiens mtDNA circular long-range numerical meta-structures are highly correlated with mtDNA diseases mutations