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Cite as: Edwin Castillo-Velarde, Gloria Montero-Pacora, Sandra García-Llajaruna. Association between hypoalbuminemia and hypophosphatemia with malnutrition in patients with Chronic Renal Disease undergoing hemodialysis. Rev. Fac. Med. Hum. July 2020; 20(3):381-387. DOI 10.25176/ RFMH.v20i3.2968 ABSTRACT Introduction: Malnutrition in hemodialysis patients is a consequence of various deficiency and hypercatabolic factors and constitutes a risk factor for morbidity and mortality. Objective: Determine the association between hypoalbuminemia and hypophosphatemia with the Subjective global assessment (SGA) C in patients with chronic renal disease on hemodialysis. Methods: Analytical crosssectional study. Patients from the hemodialysis service of the Hospital Guillermo Almenara were studied. The Kruskal-Wallis test and multiple comparisons test were used for the association between continuous variables of malnutrition and the types of SGA. The square-chi test was used for the categorical variables hypoalbuminemia (≤3.5 g/dL) and hypophosphatemia (<3 mg/dL). The association with SGA C was analyzed. Results: 131 patients were included and the median age was 63 years. 34% had hypoalbuminemia, 27% had hypophosphatemia and 14% had SGA C. 52% (68) of the patients presented alteration of at least one analyzed biomarker. Differences were found between SGA and albumin (p<0.001) and phosphorus (p=0.040). Patients with SGA C had a mean albumin of 3.1±0.74 and phosphorus of 2.88±1.54 and had a significant difference compared to those with SGA A (p<0.001 and P = 0.011, respectively). Chi-square analysis also demonstrated a significant association between SGA and hypoalbuminemia (p = 0.017) and hypophosphatemia (p=0.050). Conclusion: There is an association between SGA C and hypoalbuminemia and hypophosphatemia in patients with chronic kidney disease undergoing hemodialysis.

Association between hypoalbuminemia and hypophosphatemia with malnutrition in patients with chronic renal disease undergoing hemodialysis