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Approach for the Prediction and Analysis of Alzheimer's Disease and its Prodromal Stages, having been approved in respect to style and intellectual, is referred to you for judgment. We have read this dissertation and recommend that it be approved. iv DEDICATION I dedicate this dissertation to my parents and sister. Without their patience, understanding, support, and most of all love, the completion of this work would not have been possible. v ACKNOWLEDGMENTS I would like to express my deepest appreciation and gratitude to my major professor, Dr. Malek Adjouadi, for his patience, guidance and for supporting me during these past four years. I also have to thank all my PhD committee members, Dr. David Loewenstein from the University of Miami for providing me with data and very insightful discussions and inputs to my research. I would also like to express my gratitude to all my teachers who instructed me and made me a better person. I am highly indebted to my former colleagues Dr. Mohammed Goryawala and Dr. Jin Wang for sharing their experiences and research ideas with me. I am grateful to my colleagues at the Center for Advanced Technology and Education (CATE) for their kind advice and suggestions. I would also like to thank the CATE lab manager Ms. Niovi Rojas for the technical support she provided me. Particularly, I have to thank my beloved family and friends for their love, unwavering supports and continuous encouragements throughout my graduate studies. Finally, I am grateful for the support provided in the last year through the

An Integrated Neuroimaging Approach for the Prediction and Analysis of Alzheimer’s Disease and its Prodromal Stages