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OF THE DISSERTATION EFFECT OF BLOOD FLOW PATTERNS ON LOCALIZED PLATELET ADHESION UNDER PHYSIOLOGIC FLOW CONDITIONS USING TWO-DIMENSIONAL AND THREE-DIMENSIONAL STENT MODELS AN EXPERIMENTAL AND COMPUTATIONAL APPROACH by Nandini Duraiswamy Florida International University, 2005 Miami, Florida Professor Richard Schoephoerster, Major Professor This dissertation presents dynamic flow experiments with fluorescently labeled platelets to allow for spatial observation of wall attachrent in inter-strut spacings, to investigate their relationship to flow patterns. Human blood with fluorescently labeled platelets was circulated through an in vitro system that produced physiologic pulsatile flow in (1) a parallel plate flow chamber that contained two-dimensional (2D) stents that feature completely recirculating flow, partially recirculating flow, and completely reattached flow, and (2) a three-dimensional (3D) cylindrical tube that contained stents of various geometric designs. Flow detachment and reattachment points exhibited very low platelet deposition. Platelet deposition was very low in the recirculation regions in the 3D stents unlike the 2D stents. Deposition distal to a strut was always high in 2D and 3D stents. Spirally recirculating regions were found in 3D unlike in 2D stents, where the deposition was higher than at well-separated regions of recirculation,

Effect of blood flow patterns on localized platelet adhesion under physiologic flow conditions using two-dimensional and three-dimensional stent models - an experimental and computational approach